Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

Autoantibodies to the smaller isoform of glutamate decarboxylase can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis. The detection of disease-specific autoantibody epitopes led to the hypoth...

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Bibliographic Details
Main Authors: Mario U Manto, Jerome eHonorat, Christiane Susanne Hampe, Rafael eGuerra-Narbona, Juan Carlos eLópez Ramos, José M Delgado-García, Fumihito eSaitow, Hidenori eSuzuki, Yuchio eYanagawa, Hidehiro eMizusawa, Hiroshi eMitoma
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Autoantibodies
Stiff-Person Syndrome
gabaergic neurotransmission
patch-clamp
open field test
Balance beam
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00078/full

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