Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols
Sulfenamides are organosulfur reagents that feature labile S–N bonds and have potential applications in chemical synthesis. Here, the authors report the preparation of N-acyl sulfenamides via copper-catalyzed S-amidation of thiols with dioxazolones; These N-acyl sulfenamides can be used to prepare u...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34223-7 |
| _version_ | 1811335236430069760 |
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| author | Ziqian Bai Shiyang Zhu Yiyao Hu Peng Yang Xin Chu Gang He Hao Wang Gong Chen |
| author_facet | Ziqian Bai Shiyang Zhu Yiyao Hu Peng Yang Xin Chu Gang He Hao Wang Gong Chen |
| author_sort | Ziqian Bai |
| collection | DOAJ |
| description | Sulfenamides are organosulfur reagents that feature labile S–N bonds and have potential applications in chemical synthesis. Here, the authors report the preparation of N-acyl sulfenamides via copper-catalyzed S-amidation of thiols with dioxazolones; These N-acyl sulfenamides can be used to prepare unsymmetrical disulfides via reaction with thiols. |
| first_indexed | 2024-04-13T17:21:07Z |
| format | Article |
| id | doaj.art-1ede04ff0a504508acfb0e315e4d9904 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:21:07Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1ede04ff0a504508acfb0e315e4d99042022-12-22T02:37:58ZengNature PortfolioNature Communications2041-17232022-10-011311910.1038/s41467-022-34223-7Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiolsZiqian Bai0Shiyang Zhu1Yiyao Hu2Peng Yang3Xin Chu4Gang He5Hao Wang6Gong Chen7State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversitySulfenamides are organosulfur reagents that feature labile S–N bonds and have potential applications in chemical synthesis. Here, the authors report the preparation of N-acyl sulfenamides via copper-catalyzed S-amidation of thiols with dioxazolones; These N-acyl sulfenamides can be used to prepare unsymmetrical disulfides via reaction with thiols.https://doi.org/10.1038/s41467-022-34223-7 |
| spellingShingle | Ziqian Bai Shiyang Zhu Yiyao Hu Peng Yang Xin Chu Gang He Hao Wang Gong Chen Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols Nature Communications |
| title | Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols |
| title_full | Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols |
| title_fullStr | Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols |
| title_full_unstemmed | Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols |
| title_short | Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols |
| title_sort | synthesis of n acyl sulfenamides via copper catalysis and their use as s sulfenylating reagents of thiols |
| url | https://doi.org/10.1038/s41467-022-34223-7 |
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