Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations

Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations

Multiple clinical trials exploring the potential of adoptive natural killer (NK) cell therapy for cancer have employed ex vivo expansion using feeder cells to obtain large numbers of NK cells. We have previously utilized the rhesus macaque model to clonally track the NK cell progeny of barcode-trans...

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Bibliographic Details
Main Authors: David S.J. Allan, Chuanfeng Wu, Ryland D. Mortlock, Mala Chakraborty, Katayoun Rezvani, Jan K. Davidson-Moncada, Cynthia E. Dunbar, Richard W. Childs
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
natural killer cell
NK cell expansion
barcode tracking
NK cell repertoire
adaptive NK cells
memory NK cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001541

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http://www.sciencedirect.com/science/article/pii/S2372770522001541

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