Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation

Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation

Connexins (Cx) are proteins that form cell‐to‐cell gap junction channels. A mutation at position 188 in the second extracellular loop (E2) domain of hCx46 has been linked to an autosomal dominant zonular pulverulent cataract. As it is dominantly inherited, it is possible that the mutant variant affe...

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Bibliographic Details
Main Authors: Patrik Schadzek, Yannick Stahl, Matthias Preller, Anaclet Ngezahayo
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:FEBS Open Bio
Subjects:
cataract
concatenation
dominant inheritance
hCx46
hCx46N188T
molecular dynamics
Online Access:https://doi.org/10.1002/2211-5463.12624

Internet

https://doi.org/10.1002/2211-5463.12624

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