Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. H...

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מידע ביבליוגרפי
Main Authors: Jean-Philippe Defour, Emilie Leroy, Sharmila Dass, Thomas Balligand, Gabriel Levy, Ian C Brett, Nicolas Papadopoulos, Céline Mouton, Lidvine Genet, Christian Pecquet, Judith Staerk, Steven O Smith, Stefan N Constantinescu
פורמט: Article
שפה:English
יצא לאור: eLife Sciences Publications Ltd 2023-06-01
סדרה:eLife
נושאים:
c-mpl ligand
thrombopoietin receptor
cytokine receptor
transmembrane domain
helix dimerization
גישה מקוונת:https://elifesciences.org/articles/81521

אינטרנט

https://elifesciences.org/articles/81521

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