Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes

Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes

Pathological blood clotting, or thrombosis, limits vital blood flow to organs; such deprivation can lead to catastrophic events including myocardial infarction, pulmonary embolism, and ischemic stroke. Prompt restoration of blood flow greatly improves outcomes. We explored whether aptamers could ser...

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Bibliographic Details
Main Authors: Bethany Powell Gray, Linsley Kelly, Kady-Ann Steen-Burrell, Juliana M. Layzer, Rachel E. Rempel, Shahid M. Nimjee, Brian C. Cooley, Alice F. Tarantal, Bruce A. Sullenger
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Diagnostics and Biosensors
aptamers
RNA
imaging
thrombosis
clot imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000124

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http://www.sciencedirect.com/science/article/pii/S2162253123000124

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