The altering cellular components and function in tumor microenvironment during remissive and relapsed stages of anti-CD19 CAR T-cell treated lymphoma mice

The altering cellular components and function in tumor microenvironment during remissive and relapsed stages of anti-CD19 CAR T-cell treated lymphoma mice

Anti-CD19 chimeric antigen receptor (CAR) T cells represent a highly promising strategy for B-cell malignancies. Despite the inspiring initial achievement, remission in a notable fraction of subjects is short-lived, and relapse remains a major challenge. Tumor microenvironment (TME) was proved to be...

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Bibliographic Details
Main Authors: Kai Zhao, Chunxiao Ren, Donghai Tang, Li Zhao, Xianxian Chen, Ying Wang, Kailin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T cell
CD19
tumor microenvironment
lymphoma
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1101769/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1101769/full

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