Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in Mice

Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in Mice

Current COVID-19 vaccines can effectively reduce disease severity and hospitalisation; however, they are not considerably effective in preventing infection and transmission. In this context, mucosal vaccines are pertinent to prevent SARS-CoV-2 infection and spread. In this study, we generated a repl...

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Bibliographic Details
Main Authors: Donghong Wang, Yao Deng, Jianfang Zhou, Wen Wang, Baoying Huang, Wenling Wang, Lan Wei, Jiao Ren, Ruiwen Han, Jialuo Bing, Chengcheng Zhai, Xiaoyan Guo, Wenjie Tan
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Vaccines
Subjects:
COVID-19
influenza virus
heterologous protection
recombinant vaccine
T cell immunity
Online Access:https://www.mdpi.com/2076-393X/11/9/1453

Internet

https://www.mdpi.com/2076-393X/11/9/1453

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