Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains

Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains

ABSTRACT Collateral sensitivity and resistance occur when resistance development toward one antimicrobial either potentiates or deteriorates the effect of others. Previous reports on collateral effects on susceptibility focus on newly acquired resistance determinants and propose that novel treatment...

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Bibliographic Details
Main Authors: Vidar Sørum, Emma L. Øynes, Anna S. Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky, Pål J. Johnsen
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
Escherichia coli
antimicrobial resistance
ciprofloxacin
collateral sensitivity
compensatory mutations
Online Access:https://journals.asm.org/doi/10.1128/mbio.00441-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00441-22

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