Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Abstract Background C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-terminal tail tyrosine which stabilizes SFKs in a closed inactive conformation...

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Bibliographic Details
Main Authors: Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Cell Communication and Signaling
Subjects:
Src-family protein kinases
Tumor suppressor
Catalysis, colon cancer
C-terminal Src kinase
Csk
Chk
Online Access:http://link.springer.com/article/10.1186/s12964-017-0186-x

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http://link.springer.com/article/10.1186/s12964-017-0186-x

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