Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent
A variety of knoevenagel compounds from isatin were synthesized using an eco-friendly methodology. It was used only the binary solvent ethanol: water (3:7 v/v) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2–...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715621000400 |
| _version_ | 1831641773649166336 |
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| author | João Marcos Gomes de Oliveira Ferreira Girlyanderson Araújo da Silva Maísa Cavalcanti Coelho Claudio Gabriel Lima Junior Juliana Alves Vale |
| author_facet | João Marcos Gomes de Oliveira Ferreira Girlyanderson Araújo da Silva Maísa Cavalcanti Coelho Claudio Gabriel Lima Junior Juliana Alves Vale |
| author_sort | João Marcos Gomes de Oliveira Ferreira |
| collection | DOAJ |
| description | A variety of knoevenagel compounds from isatin were synthesized using an eco-friendly methodology. It was used only the binary solvent ethanol: water (3:7 v/v) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2–5 min and isolated yields 80–96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained 79–92% isolated yields. |
| first_indexed | 2024-12-19T12:31:04Z |
| format | Article |
| id | doaj.art-1eed5d0f1bc04995a83e3c5359b18b13 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-12-19T12:31:04Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-1eed5d0f1bc04995a83e3c5359b18b132022-12-21T20:21:24ZengElsevierResults in Chemistry2211-71562021-01-013100135Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solventJoão Marcos Gomes de Oliveira Ferreira0Girlyanderson Araújo da Silva1Maísa Cavalcanti Coelho2Claudio Gabriel Lima Junior3Juliana Alves Vale4Departamento de Química, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, BrazilDepartamento de Química, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, BrazilDepartamento de Química, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, BrazilDepartamento de Química, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, BrazilCorresponding author.; Departamento de Química, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, BrazilA variety of knoevenagel compounds from isatin were synthesized using an eco-friendly methodology. It was used only the binary solvent ethanol: water (3:7 v/v) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2–5 min and isolated yields 80–96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained 79–92% isolated yields.http://www.sciencedirect.com/science/article/pii/S2211715621000400Knoevenagel condensationBinary mixtureIsatin |
| spellingShingle | João Marcos Gomes de Oliveira Ferreira Girlyanderson Araújo da Silva Maísa Cavalcanti Coelho Claudio Gabriel Lima Junior Juliana Alves Vale Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent Results in Chemistry Knoevenagel condensation Binary mixture Isatin |
| title | Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent |
| title_full | Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent |
| title_fullStr | Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent |
| title_full_unstemmed | Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent |
| title_short | Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent |
| title_sort | quick synthesis of isatin derived knoevenagel adducts using only eco friendly solvent |
| topic | Knoevenagel condensation Binary mixture Isatin |
| url | http://www.sciencedirect.com/science/article/pii/S2211715621000400 |
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