A mixture model for signature discovery from sparse mutation data

A mixture model for signature discovery from sparse mutation data

Abstract Mutational signatures are key to understanding the processes that shape cancer genomes, yet their analysis requires relatively rich whole-genome or whole-exome mutation data. Recently, orders-of-magnitude sparser gene-panel-sequencing data have become increasingly available in the clinic. T...

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Bibliographic Details
Main Authors: Itay Sason, Yuexi Chen, Mark D.M. Leiserson, Roded Sharan
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Genome Medicine
Subjects:
Mutational signatures
Probabilistic modeling
Gene panel sequencing
Online Access:https://doi.org/10.1186/s13073-021-00988-7

Internet

https://doi.org/10.1186/s13073-021-00988-7

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