High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations

High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations

The crucial role of integrin in pathological processes such as tumor progression and metastasis formation has inspired intense efforts to design novel pharmaceutical agents modulating integrin functions in order to provide new tools for potential therapies. In the past decade, we have investigated t...

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Bibliographic Details
Main Authors: Clementina Acconcia, Antonella Paladino, Maria della Valle, Biancamaria Farina, Annarita Del Gatto, Sonia Di Gaetano, Domenica Capasso, Maria Teresa Gentile, Gaetano Malgieri, Carla Isernia, Michele Saviano, Roberto Fattorusso, Laura Zaccaro, Luigi Russo
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
integrin
structure–activity relationship
peptide dynamics
natural-abundance NMR
recognition mechanism
Online Access:https://www.mdpi.com/1422-0067/23/19/11039

Internet

https://www.mdpi.com/1422-0067/23/19/11039

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