Reversal of ABCG2/BCRP-Mediated Multidrug Resistance by 5,3′,5′-Trihydroxy-3,6,7,4′-Tetramethoxyflavone Isolated from the Australian Desert Plant <i>Eremophila galeata</i> Chinnock

Reversal of ABCG2/BCRP-Mediated Multidrug Resistance by 5,3′,5′-Trihydroxy-3,6,7,4′-Tetramethoxyflavone Isolated from the Australian Desert Plant <i>Eremophila galeata</i> Chinnock

Multidrug resistance (MDR) is a major challenge in cancer treatment, and the breast cancer resistance protein (BCRP) is an important target in the search for new MDR-reversing drugs. With the aim of discovering new potential BCRP inhibitors, the crude extract of leaves of <i>Eremophila galeata...

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Bibliographic Details
Main Authors: Malene J. Petersen, Xamuel L. Lund, Susan J. Semple, Bevan Buirchell, Henrik Franzyk, Michael Gajhede, Kenneth T. Kongstad, Jan Stenvang, Dan Staerk
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomolecules
Subjects:
<i>Eremophila galeata</i>
breast cancer resistance protein
multidrug resistance
docking
Online Access:https://www.mdpi.com/2218-273X/11/10/1534

Internet

https://www.mdpi.com/2218-273X/11/10/1534

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