Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons

Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons

The MELAS syndrome primarily affecting the CNS is mainly caused by the m.A3243G mutation. The heteroplasmy in different tissues affects the phenotypic spectrum, yet the impact of various levels of m.A3243G heteroplasmy on CNS remains elusive due to the lack of a proper neuronal model harboring m.A32...

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Bibliographic Details
Main Authors: Dar-Shong Lin, Yu-Wen Huang, Che-Sheng Ho, Tung-Sun Huang, Tsung-Han Lee, Tsu-Yen Wu, Zon-Darr Huang, Tuan-Jen Wang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
induced neurons
mitochondrial diseases
MELAS
heteroplasmy
OXPHOS
bioenergetics
Online Access:https://www.mdpi.com/2073-4409/12/1/15

Internet

https://www.mdpi.com/2073-4409/12/1/15

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