Therapeutic Adenovirus Vaccine Combined Immunization with IL-12 Induces Potent CD8<sup>+</sup> T Cell Anti-Tumor Immunity in Hepatocellular Carcinoma

Therapeutic Adenovirus Vaccine Combined Immunization with IL-12 Induces Potent CD8<sup>+</sup> T Cell Anti-Tumor Immunity in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the cancers with the highest morbidity and mortality in the world. However, clinical progress in the treatment of HCC has not shown a satisfactory therapeutic effect. Here, we have developed a novel strategy to treat HCC with an adenovirus (Ad)-based vaccine,...

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Bibliographic Details
Main Authors: Yanyan Zheng, Zheng Lu, Jiage Ding, Nan Jiang, Jiawei Wang, Jie Yang, Jingyuan Song, Hongliang Chen, Lin Fang, Huizhong Li, Hui Tian, Gang Wang, Junnian Zheng, Dafei Chai
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
HCC
Ad vaccine
GPC3
IL-12
CD8<sup>+</sup> DCs
multifunctional CD8<sup>+</sup> T cells
Online Access:https://www.mdpi.com/2072-6694/14/18/4512

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https://www.mdpi.com/2072-6694/14/18/4512

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