Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes

Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes

Abstract Background Toxoplasma gondii infection during pregnancy can lead to fetal defect(s) or congenital complications. The inhibitory molecule B7-H4 expressed on decidual macrophages (dMφ) plays an important role in maternal–fetal tolerance. However, the effect of B7-H4 on the function of dMφ dur...

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Bibliographic Details
Main Authors: Lijun Cui, Yu Wang, Liqin Ren, Zhidan Li, Yuzhu Jiang, Chao Wang, Xianbing Liu, Yushan Ren, Xuemei Hu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Parasites & Vectors
Subjects:
Toxoplasma gondii
Decidual macrophage
B7-H4
Abnormal pregnancy
Adoptive transfer
Online Access:https://doi.org/10.1186/s13071-022-05560-9

Internet

https://doi.org/10.1186/s13071-022-05560-9

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