POTN: A Human Leukocyte Antigen-A2 Immunogenic Peptides Screening Model and Its Applications in Tumor Antigens Prediction

POTN: A Human Leukocyte Antigen-A2 Immunogenic Peptides Screening Model and Its Applications in Tumor Antigens Prediction

Whole genome/exome sequencing data for tumors are now abundant, and many tumor antigens, especially mutant antigens (neoantigens), have been identified for cancer immunotherapy. However, only a small fraction of the peptides from these antigens induce cytotoxic T cell responses. Therefore, efficient...

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Bibliographic Details
Main Authors: Qingqing Meng, Yahong Wu, Xinghua Sui, Jingjie Meng, Tingting Wang, Yan Lin, Zhiwei Wang, Xiuman Zhou, Yuanming Qi, Jiangfeng Du, Yanfeng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
neoantigen prediction
peptides
immunogenicity
prediction model
cancer immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02193/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.02193/full

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