Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice

Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice

Ultraviolet (UV) radiation is one of the most genotoxic, universal agents present in the environment. UVB (280-315 nm) radiation directly damages DNA, producing cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6-4 pyrimidone photoproducts (6-4PPs). These photolesions interfere with essential cell...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Gustavo S. Kajitani, Carolina Quayle, Camila C. M. Garcia, Wesley L. Fotoran, Juliana F. R. dos Santos, Gijsbertus T. J. van der Horst, Jan H. J. Hoeijmakers, Carlos F. M. Menck
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2022-03-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
photolesions
photolyase
nucleotide excision repair
xeroderma pigmentosum
UVB ultraviolet radiation
inflammation
Online Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.800606/full

Online

https://www.frontiersin.org/articles/10.3389/fimmu.2022.800606/full

Ähnliche Einträge