A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis
Biophysical approaches reveal how a mutation in the constant light chain domain of a patient-derived antibody destabilizes the constant domain, prevents the dimerization of the light chain, and makes it more prone to proteolytic cleavage, unleashing the amyloidogenic potential of the isolated variab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04574-y |