Substantial restoration of night vision in adult mice with congenital stationary night blindness

Substantial restoration of night vision in adult mice with congenital stationary night blindness

Complete congenital stationary night blindness (cCSNB) due to mutations in TRPM1, GRM6, GPR179, NYX, or leucine-rich repeat immunoglobulin-like transmembrane domain 3 (LRIT3) is an incurable inherited retinal disorder characterized by an ON-bipolar cell (ON-BC) defect. Since the disease is non-degen...

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Bibliographic Details
Main Authors: Juliette Varin, Nassima Bouzidi, Gregory Gauvain, Corentin Joffrois, Melissa Desrosiers, Camille Robert, Miguel Miranda De Sousa Dias, Marion Neuillé, Christelle Michiels, Marco Nassisi, José-Alain Sahel, Serge Picaud, Isabelle Audo, Deniz Dalkara, Christina Zeitz
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
congenital stationary night blindness
CSNB
LRIT3
bipolar cells
photoreceptors
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000929

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http://www.sciencedirect.com/science/article/pii/S2329050121000929

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