<i>N</i>-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells

<i>N</i>-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells

Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides being respectively inv...

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Bibliographic Details
Main Authors: Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
hydrogen sulfide
sulfane sulfur species
enzymatic activity assays
protein expression levels
antioxidants
colorectal cancer
Online Access:https://www.mdpi.com/2073-4409/8/8/828

Internet

https://www.mdpi.com/2073-4409/8/8/828

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