SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts

SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts

Emerging evidence indicates that aberrant maternal inflammation is associated with several pregnancy-related disorders such as preeclampsia, preterm birth, and intrauterine growth restriction. Sirtuin1 (SIRT1), a class III histone deacetylase, is involved in the regulation of various physiopathologi...

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Bibliographic Details
Main Authors: Sumi Park, Jiha Shin, Jeongyun Bae, Daewon Han, Seok-Rae Park, Jongdae Shin, Sung Ki Lee, Hwan-Woo Park
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
sirt1
nlrp3 inflammasome
maternal inflammation
human trophoblasts
placenta
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/9/3/728

Internet

https://www.mdpi.com/2073-4409/9/3/728

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