Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

This study describes the development and characterization of peptidomimetic inhibitors of TMPRSS2, which primes the Spike protein of SARS-CoV-2. The inhibitors are shown to prevent SARS-CoV-2 infection in cells as efficiently as camostat mesylate.

Bibliographic Details
Main Authors: Lukas Wettstein, Philip Maximilian Knaff, Christian Kersten, Patrick Müller, Tatjana Weil, Carina Conzelmann, Janis A Müller, Maximilian Brückner, Markus Hoffmann, Stefan Pöhlmann, Tanja Schirmeister, Katharina Landfester, Jan Münch, Volker Mailänder
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03613-4

Internet

https://doi.org/10.1038/s42003-022-03613-4

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