Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of TOR1A dystonia

TOR1A-associated dystonia, otherwise known as DYT1 dystonia, is an inherited dystonia caused by a three base-pair deletion in the TOR1A gene (TOR1AΔE). Although the mechanisms underlying the dystonic movements are largely unknown, abnormalities in striatal dopamine and acetylcholine neurotransmissio...

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Bibliografiske detaljer
Main Authors: Anthony M. Downs, Xueliang Fan, Radhika F. Kadakia, Yuping Donsante, H.A. Jinnah, Ellen J. Hess
Format: Article
Sprog:English
Udgivet: Elsevier 2021-07-01
Serier:Neurobiology of Disease
Fag:
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996121001182