Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP

Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP

Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate inflammation but have little or no ionotropic activity, are of outstanding clinical interest for the prevention and therapy o...

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Bibliographic Details
Main Authors: Katrin Richter, Roger L. Papke, Clare Stokes, Danika C. Roy, Eduardo S. Espinosa, Philipp M. K. Wolf, Andreas Hecker, Juliane Liese, Vijay K. Singh, Winfried Padberg, Klaus-Dieter Schlüter, Marius Rohde, J. Michael McIntosh, Barbara J. Morley, Nicole A. Horenstein, Veronika Grau, Alain R. Simard
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CHRNA7
CHRNA9
CHRNA10
cytokines
inflammation
silent agonist
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.779081/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.779081/full

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