AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in obstructive hydrocephalus

AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in obstructive hydrocephalus

Abstract Hydrocephalus is a distension of the ventricular system associated with ventricular zone disruption, reactive astrogliosis, periventricular white matter ischemia, axonal impairment, and corpus callosum alterations. The condition's etiology is typically attributed to a malfunction in cl...

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Bibliographic Details
Main Authors: Leandro Castañeyra-Ruiz, Ibrahim González-Marrero, Luis G. Hernández-Abad, Emilia M. Carmona-Calero, Marta R. Pardo, Rebeca Baz-Davila, Seunghyun Lee, Michael Muhonen, Ricardo Borges, Agustín Castañeyra-Perdomo
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Acta Neuropathologica Communications
Subjects:
AQP4
Hydrocephalus
Gliogenesis
Glial stem cells
Reactive astrogliosis
Microvesicles
Online Access:https://doi.org/10.1186/s40478-022-01345-4

Internet

https://doi.org/10.1186/s40478-022-01345-4

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