Bortezomib Inhibits Multiple Myeloma Cells by Transactivating ATF3 to Trigger miR-135a-5p- Dependent Apoptosis

Bortezomib Inhibits Multiple Myeloma Cells by Transactivating ATF3 to Trigger miR-135a-5p- Dependent Apoptosis

Multiple myeloma (MM) is a malignant cancer with an increasing in incidence that can be alleviated through bortezomib (BTZ) treatment. Activating transcription factor 3 (ATF3) plays a major role in cancer development. Moreover, microRNAs (miRNAs) regulate carcinogenic pathways, apoptosis, and progra...

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Bibliographic Details
Main Authors: Xiaolan Lai, Chuanqian Huang, Xuekun Nie, Qi Chen, Yirong Tang, Xianguo Fu, Ying Lin, Chengjun Nie, Xinyu Xu, Xiukang Wang, Renli Chen, Zichun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
bortezomib
miR-135a-5p
ATF3
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.720261/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.720261/full

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