Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer

Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer

Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (GAPDH, PKM2, GSTP1, SPATA5, MFF, TSPOAP1, PHB2, COA4, and HAGH) rec...

Full description

Bibliographic Details
Main Authors: Deya Obaidat, Roberta Giordo, Erica L. Kleinbrink, Emilia Banisad, Lawrence I. Grossman, Rooshan Arshad, Azadeh Stark, Marie-Claire Maroun, Leonard Lipovich, Félix Fernandez-Madrid
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Genetics
Subjects:
breast cancer
mitochondria
autoimmunity
long non-coding RNA
carcinogenesis
phage display
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.970619/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.970619/full

Similar Items