New Chemotypes for the Inhibition of (p)ppGpp Synthesis in the Quest for New Antimicrobial Compounds

New Chemotypes for the Inhibition of (p)ppGpp Synthesis in the Quest for New Antimicrobial Compounds

Antimicrobial resistance (AMR) poses a serious threat to our society from both the medical and economic point of view, while the antibiotic discovery pipeline has been dwindling over the last decades. Targeting non-essential bacterial pathways, such as those leading to antibiotic persistence, a bact...

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Bibliographic Details
Main Authors: Crescenzo Coppa, Luca Sorrentino, Monica Civera, Marco Minneci, Francesca Vasile, Sara Sattin
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
AMR
persisters
(p)ppGpp
fragment screening
thermal shift assay
STD-NMR
Online Access:https://www.mdpi.com/1420-3049/27/10/3097

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https://www.mdpi.com/1420-3049/27/10/3097

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