Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines

Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines

The complexity of chemical components of herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential of a pair of stilbene isomers in a famous traditional Chinese herb, Polygonum multiflorum (Heshouwu in Chinese...

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Bibliographic Details
Main Authors: Juan Liu, Tingting Li, Ruihong Li, Jie Wang, Pengyan Li, Ming Niu, Le Zhang, Chunyu Li, Tao Wang, Xiaohe Xiao, Jia-bo Wang, Yunfang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
hepatotoxicity
organoids
high-content imaging
stereoisomer
Polygonum multiflorum
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.862830/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.862830/full

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