Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS) is an intractable adult-onset neurodegenerative disease that leads to the loss of upper and lower motor neurons (MNs). The long axons of MNs become damaged during the early stages of ALS. Genetic and pathological analyses of ALS patients have revealed dysfunction...

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Bibliographic Details
Main Authors: Naoki Suzuki, Tetsuya Akiyama, Hitoshi Warita, Masashi Aoki
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
omics analysis
axonal dysfunction
local translation
axon branching
motor nerve organoid
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00194/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00194/full

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