IL-25 blockade inhibits metastasis in breast cancer
Abstract Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2016-12-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-016-0345-7 |
| _version_ | 1797722184181874688 |
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| author | Zhujun Jiang Jingtao Chen Xuemei Du Hang Cheng Xiaohu Wang Chen Dong |
| author_facet | Zhujun Jiang Jingtao Chen Xuemei Du Hang Cheng Xiaohu Wang Chen Dong |
| author_sort | Zhujun Jiang |
| collection | DOAJ |
| description | Abstract Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4+ T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor. |
| first_indexed | 2024-03-12T09:44:50Z |
| format | Article |
| id | doaj.art-1f223dfc19c842d4a05be59a58d66bdd |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T09:44:50Z |
| publishDate | 2016-12-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-1f223dfc19c842d4a05be59a58d66bdd2023-09-02T12:58:16ZengOxford University PressProtein & Cell1674-800X1674-80182016-12-018319120110.1007/s13238-016-0345-7IL-25 blockade inhibits metastasis in breast cancerZhujun Jiang0Jingtao Chen1Xuemei Du2Hang Cheng3Xiaohu Wang4Chen Dong5Institute for Immunology and School of Medicine, Tsinghua UniversityInstitute of Translational Medicine, The First Hospital, Jilin UniversityDepartment of Pathology, Beijinɡ Shijitan Hospital of Capital Medical UniversityInstitute of Translational Medicine, The First Hospital, Jilin UniversityInstitute for Immunology and School of Medicine, Tsinghua UniversityInstitute for Immunology and School of Medicine, Tsinghua UniversityAbstract Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4+ T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.http://link.springer.com/article/10.1007/s13238-016-0345-7IL-25breast cancermetastasisMMTV-PyMT |
| spellingShingle | Zhujun Jiang Jingtao Chen Xuemei Du Hang Cheng Xiaohu Wang Chen Dong IL-25 blockade inhibits metastasis in breast cancer Protein & Cell IL-25 breast cancer metastasis MMTV-PyMT |
| title | IL-25 blockade inhibits metastasis in breast cancer |
| title_full | IL-25 blockade inhibits metastasis in breast cancer |
| title_fullStr | IL-25 blockade inhibits metastasis in breast cancer |
| title_full_unstemmed | IL-25 blockade inhibits metastasis in breast cancer |
| title_short | IL-25 blockade inhibits metastasis in breast cancer |
| title_sort | il 25 blockade inhibits metastasis in breast cancer |
| topic | IL-25 breast cancer metastasis MMTV-PyMT |
| url | http://link.springer.com/article/10.1007/s13238-016-0345-7 |
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