Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells

Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells

SGLT2 inhibitors (SGLT2i) slow the progression of chronic kidney disease; however, evidence for the underlying molecular mechanisms is scarce. We investigated SGLT2i-mediated effects on differential gene expression in two independent human proximal tubular cell (HPTC) lines (HK-2 and RPTEC/TERT1) at...

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Bibliographic Details
Main Authors: Markus Pirklbauer, Maximilian Bernd, Lisa Fuchs, Petra Staudinger, Ulrike Corazza, Johannes Leierer, Gert Mayer, Herbert Schramek
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
SGLT2 inhibition
interleukin-1β
MCP-1/CCL2
endothelin-1
human proximal tubular cell
Online Access:https://www.mdpi.com/1422-0067/21/21/8189

Internet

https://www.mdpi.com/1422-0067/21/21/8189

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