Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors

Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors

Human genetics has identified rare copy number variations and deleterious mutations for all neurexin genes (NRXN1-3) in patients with neurodevelopmental diseases, and electrophysiological recordings in animal brains have shown that Nrxns are important for synaptic transmission. While several mouse m...

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Bibliographic Details
Main Authors: Gesche eBorn, Hannah Mary Grayton, Hanna eLanghorst, Irina eDudanova, Astrid eRohlmann, Benjamin eWoodward, David eCollier, Cathy eFernandes, Markus eMissler
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Cognition
AMPA receptor
autism
synaptic plasticity
mouse models
Electron microscopy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00003/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00003/full

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