Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart

Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart

Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac contractility and hemodynamics are not known. Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation (G7, G6, G5, G4 and G3) and surface chemistry (-NH<sub>2</sub>, -C...

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Bibliographic Details
Main Authors: Saghir Akhtar, Fawzi Babiker, Usman A. Akhtar, Ibrahim F. Benter
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
PAMAM dendrimer
Ang-(1-7)
cardiac ischemia/reperfusion
Mas receptor
surface chemistry
dendrimer generation
Online Access:https://www.mdpi.com/1999-4923/14/12/2673

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https://www.mdpi.com/1999-4923/14/12/2673

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