Gambogenic Acid Induces Endoplasmic Reticulum Stress in Colorectal Cancer via the Aurora A Pathway

Gambogenic Acid Induces Endoplasmic Reticulum Stress in Colorectal Cancer via the Aurora A Pathway

Colorectal cancer (CRC) is one of the most common malignancies in the world and has a poor prognosis. In the present research, gambogenic acid (GNA), isolated from the traditional Chinese medicine gamboge, markedly induced apoptosis and inhibited the proliferation of CRC in vitro and in vivo. Furthe...

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Bibliographic Details
Main Authors: Cheng Liu, Jiaxin Xu, Chenxu Guo, Xugang Chen, Chunmei Qian, Xing Zhang, Pinghong Zhou, Yifu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gambogenic acid
endoplasmic reticulum stress
Aurora A
colorectal cancer
eukaryotic translation initiation factor 2α
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.736350/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.736350/full

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