Molecular homology between canine spontaneous oral squamous cell carcinomas and human head-and-neck squamous cell carcinomas reveals disease drivers and therapeutic vulnerabilities

Molecular homology between canine spontaneous oral squamous cell carcinomas and human head-and-neck squamous cell carcinomas reveals disease drivers and therapeutic vulnerabilities

Spontaneously occurring canine oral squamous cell carcinomas (COSCC) are viewed as a useful model for human head and neck squamous cell carcinomas (HNSCC). To date however, the molecular basis of COSCC remains poorly understood. To identify changes pertinent to cancer cells in COSCC, we specifically...

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Bibliographic Details
Main Authors: Franco Guscetti, Sina Nassiri, Erin Beebe, Inês Rito Brandao, Ramona Graf, Enni Markkanen
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Comparative oncology
Laser-capture microdissection
FFPE tissue
RNA sequencing
palbociclib
CDK4/CDK6
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301585

Internet

http://www.sciencedirect.com/science/article/pii/S1476558620301585

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