Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis

Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis

BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer, glycosylation in clinical breast cancer (BC) metastasis has not yet been studied. While preclinical studies show that the glycocalyx coating of cancer cells is involved in adhesion, migration, and metastasis, glycosyl...

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Bibliographic Details
Main Authors: Klára Ščupáková, Oluwatobi T. Adelaja, Benjamin Balluff, Vinay Ayyappan, Caitlin M. Tressler, Nicole M. Jenkinson, Britt S.R. Claes, Andrew P. Bowman, Ashley M. Cimino-Mathews, Marissa J. White, Pedram Argani, Ron M.A. Heeren, Kristine Glunde
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-12-01
Series:JCI Insight
Subjects:
Oncology
Online Access:https://doi.org/10.1172/jci.insight.146945

Internet

https://doi.org/10.1172/jci.insight.146945

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