Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus

Two Novel Phenylpropanoid Trimers From Ligusticum chuanxiong Hort With Inhibitory Activities on Alpha-Hemolysin Secreted by Staphylococcus aureus

The emergence of antibiotic resistance in Staphylococcus aureus has necessitated the development of innovative anti-infective agents acting on novel targets. Alpha-hemolysin (Hla), a key virulence factor of S. aureus, is known to cause various cell damage and death. In this study, with bioassay-guid...

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Bibliographic Details
Main Authors: Shi-Jie Wan, Han-Gui Ren, Jia-Ming Jiang, Gang Xu, Yu Xu, Si-Min Chen, Gan Chen, Dan Zheng, Man Yuan, Hong Zhang, Hong-Xi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Chemistry
Subjects:
Staphylococcus aureus
alpha-hemolysin
Ligusticum chuanxiong Hort
lignan
anti-virulence
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.877469/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.877469/full

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