Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant

Abstract PIK3CA mutations are the most common in breast cancer, particularly in the estrogen receptor-positive cohort, but the benefit of PI3K inhibitors has had limited success compared with approaches targeting other less common mutations. We found a frequent allelic expression imbalance between t...

Full description

Bibliographic Details
Main Authors: Lizelle Correia, Ramiro Magno, Joana M. Xavier, Bernardo P. de Almeida, Isabel Duarte, Filipa Esteves, Marinella Ghezzo, Matthew Eldridge, Chong Sun, Astrid Bosma, Lorenza Mittempergher, Ana Marreiros, Rene Bernards, Carlos Caldas, Suet-Feung Chin, Ana-Teresa Maia
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00435-9

Internet

https://doi.org/10.1038/s41523-022-00435-9

Similar Items