Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation. Mitochondrial dysfunction of complex I has been implicated in the pathophysiology of SAMS. The present study pro...

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Bibliographic Details
Main Authors: Vlad F. Avram, Imen Chamkha, Eleonor Åsander-Frostner, Johannes K. Ehinger, Romulus Z. Timar, Magnus J. Hansson, Danina M. Muntean, Eskil Elmér
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
platelets
HepG2 cells
statins
cell-permeable succinate
NV118
mitochondria
Online Access:https://www.mdpi.com/1422-0067/22/1/424

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https://www.mdpi.com/1422-0067/22/1/424

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