Differential influence of levodopa on reward-based learning in Parkinson's disease

Differential influence of levodopa on reward-based learning in Parkinson's disease

The mesocorticolimbic dopamine (DA) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. Within this system, coexistent segregated striato-frontal circuits have been linked to different funct...

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Bibliographic Details
Main Authors: Susanne Graef, Guido Biele, Lea K Krugel, Frank Marzinzik, Michael Wahl, Johann Wotka, Fabian Klostermann, Hauke R Heekeren
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-10-01
Series:Frontiers in Human Neuroscience
Subjects:
Levodopa
Reversal Learning
decision-making
reinforcement learning
overdose hypothesis
PD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnhum.2010.00169/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnhum.2010.00169/full

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