Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis

Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis

Leishmania (Viannia) braziliensis induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis. Patients with CL develop a cell-mediated Th1 immune response accompanied by production of inflammatory cytokines,...

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Bibliographic Details
Main Authors: Luciana P. Covre, Régia F. Martins, Oliver P. Devine, Emma S. Chambers, Milica Vukmanovic-Stejic, Juliana A. Silva, Reynaldo Dietze, Rodrigo R. Rodrigues, Herbert L. de Matos Guedes, Aloísio Falqueto, Arne N. Akbar, Daniel C. O. Gomes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
cutaneous leishmaniasis
immunosenescence
inflammation
SASP-analogous
L. braziliensis
T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03001/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03001/full

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