Low XIST expression in Sertoli cells of Klinefelter syndrome patients causes high susceptibility of these cells to an extra X chromosome

Low XIST expression in Sertoli cells of Klinefelter syndrome patients causes high susceptibility of these cells to an extra X chromosome

Klinefelter syndrome (KS) is the most common genetic cause of human male infertility. However, the effect of the extra X chromosome on different testicular cell types remains poorly understood. Here, we profiled testicular single-cell transcriptomes from three KS patients and normal karyotype contro...

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Bibliographic Details
Main Authors: Liang-Yu Zhao, Peng Li, Chen-Cheng Yao, Ru-Hui Tian, Yu-Xin Tang, Yu-Zhuo Chen, Zhi Zhou, Zheng Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Asian Journal of Andrology
Subjects:
klinefelter syndrome; nonobstructive azoospermia; sertoli cell; spermatogenesis; x chromosome inactivation
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=6;spage=662;epage=673;aulast=Zhao

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=6;spage=662;epage=673;aulast=Zhao

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