Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice

Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice

Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular...

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Bibliographic Details
Main Authors: Wiwit Ananda Wahyu Setyaningsih, Nur Arfian, Efrayim Suryadi, Untung Tranggono, Dwi Cahyani Ratna Sari, Muhammad Mansyur Romi
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2018-03-01
Series:Iranian Journal of Medical Sciences
Subjects:
Hyperuricemia
Tubular injury
E-cadherin gene expression
Vimentin
gene expression
Wnt5a/Ror2
Online Access:http://ijms.sums.ac.ir/index.php/IJMS/article/view/3360

Internet

http://ijms.sums.ac.ir/index.php/IJMS/article/view/3360

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