Somatic and de novo Germline Variants of MEDs in Human Neural Tube Defects

Somatic and de novo Germline Variants of MEDs in Human Neural Tube Defects

BackgroundNeural tube defects (NTDs) are among the most common and severe congenital defects in humans. Their genetic etiology is complex and remains poorly understood. The Mediator complex (MED) plays a vital role in neural tube development in animal models. However, no studies have yet examined th...

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Bibliographic Details
Main Authors: Tian Tian, Xuanye Cao, Yongyan Chen, Lei Jin, Zhiwen Li, Xiao Han, Ying Lin, Bogdan J. Wlodarczyk, Richard H. Finnell, Zhengwei Yuan, Linlin Wang, Aiguo Ren, Yunping Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neural tube defects
MEDs
somatic variants
de novo variant
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.641831/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.641831/full

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