Hotspots of single-strand DNA “breakome” are enriched at transcriptional start sites of genes

Hotspots of single-strand DNA “breakome” are enriched at transcriptional start sites of genes

Single-strand breaks (SSBs) represent one of the most common types of DNA damage, yet not much is known about the genome landscapes of this type of DNA lesions in mammalian cells. Here, we found that SSBs are more likely to occur in certain positions of the human genome—SSB hotspots—in different cel...

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Bibliographic Details
Main Authors: Huifen Cao, Yufei Zhang, Ye Cai, Lu Tang, Fan Gao, Dongyang Xu, Philipp Kapranov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
DNA damage
breakome
single-strand breaks
DNA break hotspot
transcription start site
promoter
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.895795/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.895795/full

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