Construction of a Matrix Cancer-Associated Fibroblast Signature Gene-Based Risk Prognostic Signature for Directing Immunotherapy in Patients with Breast Cancer Using Single-Cell Analysis and Machine Learning

Construction of a Matrix Cancer-Associated Fibroblast Signature Gene-Based Risk Prognostic Signature for Directing Immunotherapy in Patients with Breast Cancer Using Single-Cell Analysis and Machine Learning

Cancer-associated fibroblasts (CAFs) are heterogeneous constituents of the tumor microenvironment involved in the tumorigenesis, progression, and therapeutic responses of tumors. This study identified four distinct CAF subtypes of breast cancer (BRCA) using single-cell RNA sequencing (RNA-seq) data....

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Bibliographic Details
Main Authors: Biaojie Huang, Qiurui Chen, Zhiyun Ye, Lin Zeng, Cuibing Huang, Yuting Xie, Rongxin Zhang, Han Shen
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
breast-invasive carcinoma
immunotherapy
machine learning
single-cell sequencing
cancer-associated fibroblasts
Online Access:https://www.mdpi.com/1422-0067/24/17/13175

Internet

https://www.mdpi.com/1422-0067/24/17/13175

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