Increased prime edit rates in KCNQ2 and SCN1A via single nicking all-in-one plasmids

Increased prime edit rates in KCNQ2 and SCN1A via single nicking all-in-one plasmids

Abstract Background Prime editing (PE) is the most recent gene editing technology able to introduce targeted alterations to the genome, including single base pair changes, small insertions, and deletions. Several improvements to the PE machinery have been made in the past few years, and these have b...

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Bibliographic Details
Main Authors: N. Dirkx, Wout J. Weuring, E. De Vriendt, N. Smal, J. van de Vondervoort, Ruben van ’t Slot, M. Koetsier, N. Zonnekein, Tim De Pooter, S. Weckhuysen, B. P. C. Koeleman
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Biology
Subjects:
Prime editing
EIEE
CRISPR
SCN1A
KCNQ2
Developmental and epileptic encephalopathy
Online Access:https://doi.org/10.1186/s12915-023-01646-7

Internet

https://doi.org/10.1186/s12915-023-01646-7

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